Over-Expression of DSCAM and COL6A2 Cooperatively Generates Congenital Heart Defects
نویسندگان
چکیده
منابع مشابه
Over-Expression of DSCAM and COL6A2 Cooperatively Generates Congenital Heart Defects
A significant current challenge in human genetics is the identification of interacting genetic loci mediating complex polygenic disorders. One of the best characterized polygenic diseases is Down syndrome (DS), which results from an extra copy of part or all of chromosome 21. A short interval near the distal tip of chromosome 21 contributes to congenital heart defects (CHD), and a variety of in...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2011
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1002344